Indole-3-Carbinol Monograph

Introduction Indole-3-carbinol (I3C) is a compound found in high concentrations in Brassica family vegetables, including broccoli, cauliflower, Brussels sprouts, and cabbage. As a nutritional supplement, I3C has received attention in recent years as a promising preventive and treatment agent for breast and other types of cancers, and may have beneficial effect in the management of Herpes simplex virus (HSV) and human papilloma virus (HPV). Preliminary studies have examined its efficacy, safety, and optimal dosage. Early studies have been promising, and will likely be followed by larger clinical trials.